Denosumab, a human monoclonal antibody against RANK ligand, is shown to have strong anti-fracture effects in Japanese osteoporosis patients.However, there have been no data showing actions on Japanese bone architecture.Here Vinegars we show that denosumab continuously improves several geometrical parameters calculated by hip structural analysis for
A microbial clock provides an accurate estimate of the postmortem interval in a mouse model system
Establishing the time since death is critical in every death investigation, yet existing techniques are susceptible to a range of errors and biases.For example, forensic entomology is widely used to assess the postmortem interval (PMI), but errors can range from days to months.Microbes may provide Accessories a novel method for estimating PMI that
A dysmorphic mouse model reveals developmental interactions of chondrocranium and dermatocranium
The cranial endo and dermal skeletons, which comprise the vertebrate skull, evolved independently over 470 million years ago and form separately during embryogenesis.In mammals, much of the cartilaginous chondrocranium is transient, undergoing endochondral ossification or disappearing, so its role in skull morphogenesis is not well studied and it r